Plant Transcription Factor Database
Previous version: v3.0
Raphanus raphanistrum
NF-YA Family
Species TF ID Description
RrC13986_p2NF-YA family protein
RrC14130_p1NF-YA family protein
RrC14313_p1NF-YA family protein
RrC15896_p2NF-YA family protein
RrC19079_p1NF-YA family protein
RrC2310_p3NF-YA family protein
RrC23110_p1NF-YA family protein
RrC2321_p3NF-YA family protein
RrC2575_p4NF-YA family protein
RrC2757_p1NF-YA family protein
RrC387_p6NF-YA family protein
RrC441_p9NF-YA family protein
RrC463_p9NF-YA family protein
RrC5535_p3NF-YA family protein
RrC6992_p1NF-YA family protein
RrC7189_p2NF-YA family protein
RrC7363_p1NF-YA family protein
RrC7975_p1NF-YA family protein
RrC866_p1NF-YA family protein
RrC875_p3NF-YA family protein
RrC9741_p1NF-YA family protein
NF-YA Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982